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受感染但未患病的獾在獾结核病发病机制中的作用。

Role of infected, non-diseased badgers in the pathogenesis of tuberculosis in the badger.

作者信息

Gallagher J, Monies R, Gavier-Widen M, Rule B

机构信息

Veterinary Investigation Centre, Starcross, Exeter.

出版信息

Vet Rec. 1998 Jun 27;142(26):710-4. doi: 10.1136/vr.142.26.710.

Abstract

The lungs and kidneys of 15 badgers which had no visible lesions of tuberculosis but from which Mycobacterium bovis was isolated from pooled collections of lymph nodes were serially sectioned. Lesions of tuberculosis were detected by histopathology in the the lungs of 13 and in the kidneys of one of them. The lesions were mostly typical early stage granuloma-lesions which were considered to be the primary foci of infection. These lesions suggest an early containment phase of arrested development previously not observed and provide further evidence on which to propose a hypothesis for the pathogenesis of tuberculosis in the badger.

摘要

对15只獾的肺和肾进行了连续切片,这些獾没有可见的结核病变,但从淋巴结的汇集样本中分离出了牛分枝杆菌。通过组织病理学在13只獾的肺和其中1只獾的肾中检测到了结核病变。这些病变大多是典型的早期肉芽肿病变,被认为是感染的原发灶。这些病变提示了一个以前未观察到的早期遏制阶段,即发育停滞,并为提出獾结核病发病机制的假说提供了进一步的证据。

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