Koterov A N, Trebenok Z A, Pushkareva N B, Nikol'skiĭ A V
State Research Center of Russia, Institute of Biophysics, Moscow.
Radiats Biol Radioecol. 1998 May-Jun;38(3):426-31.
It was shown, that rat hepatic Zn-metallothionein (Zn-MT) depressed in vitro Fe3+/ADP-induced lipid peroxidation (LP) in rat bone marrow cells and increased its viability after pro-oxidant's influences. ZnCl2 and its combination with cysteine also decreased LP products level, but less and did not alter viability. On 9-th day after gamma-irradiation (6 Gy) in mice protected with Zn-MT the LP products level in bone marrow was decreased in considerable extent.
结果表明，大鼠肝脏锌金属硫蛋白（Zn-MT）在体外可抑制大鼠骨髓细胞中Fe3+/ADP诱导的脂质过氧化（LP），并在受到促氧化剂影响后提高其活力。氯化锌及其与半胱氨酸的组合也降低了LP产物水平，但降低程度较小且未改变细胞活力。在接受6 Gyγ射线照射的小鼠中，用Zn-MT保护后，第9天骨髓中LP产物水平大幅降低。
