低剂量干扰素治疗对视诱发电位的影响。

The effect of low-dose interferon treatment on visual evoked potentials.

作者信息

Moschos M, Manesis E, Panagakis E, Brouzas D, Hadziyannis S, Theodossiadis G

机构信息

University Eye Clinic of Athens, Greece.

出版信息

Doc Ophthalmol. 1997;94(3):215-21. doi: 10.1007/BF02582980.

DOI:10.1007/BF02582980

PMID:9682991

Abstract

Patients suffering from chronic viral hepatitis, treated with interferon alpha-2b in a dose of 3 million units trice weekly subcutaneously, were studied. The influence of interferon on the optic nerve was evaluated by measuring the P100 implicit time of the visual evoked potentials. The results before the treatment were compared with those after 6 and 12 months of therapy, as well as with those of normal subjects. There were statistically significant differences between the groups. Furthermore, in 10 of 56 eyes (17.8%) after 6 months of treatment, and 8 of 22 eyes (36.3%) after 12 months of treatment, the P100 was abnormally delayed. The long term neurovisual effects of low-dose interferon are currently under investigation.

摘要

对患有慢性病毒性肝炎、接受皮下注射剂量为每周三次、每次300万单位的α-2b干扰素治疗的患者进行了研究。通过测量视觉诱发电位的P100潜伏期来评估干扰素对视神经的影响。将治疗前的结果与治疗6个月和12个月后的结果以及正常受试者的结果进行比较。各组之间存在统计学上的显著差异。此外，治疗6个月后，56只眼中有10只（17.8%），治疗12个月后，22只眼中有8只（36.3%）的P100潜伏期异常延长。低剂量干扰素的长期神经视觉效应目前正在研究中。