Eller A W, Bontempo F A, Faruki H, Hassett A C
Department of Ophthalmology, University of Pittsburgh School of Medicine, The Eye and Ear Institute, PA 15213, USA.
Am J Ophthalmol. 1998 Jul;126(1):146-9. doi: 10.1016/s0002-9394(98)00083-x.
To illustrate a case of peripheral retinal neovascularization (Eales disease) in a patient who tested positive for the factor V Leiden mutation.
A 42-year-old woman had a 1-week history of blurred vision in her right eye. Her medical history was remarkable for a cerebrovascular accident. Ophthalmoscopy of the right eye disclosed a mild vitreous hemorrhage and a ridge of retinal neovascularization in the temporal periphery. The left fundus showed evidence of temporal retinal ischemia. A laboratory evaluation for hypercoagulability was positive for factor V Leiden mutation.
Peripheral scatter laser photocoagulation was applied to the ischemic retina, and the neovascularization regressed. The patient began taking warfarin sodium to prevent further thrombotic events.
A laboratory evaluation for coagulopathy, including the factor V Leiden mutation, should be added to the examination of patients with Eales disease, especially individuals with a history of a previous thrombotic event.
阐述一例伴有凝血因子V莱顿突变阳性的周边视网膜新生血管形成（伊尔斯病）患者的病例。
一名42岁女性右眼视力模糊1周。她有脑血管意外病史。右眼检眼镜检查发现轻度玻璃体积血和颞侧周边视网膜新生血管嵴。左眼眼底显示颞侧视网膜缺血迹象。高凝状态实验室评估显示凝血因子V莱顿突变阳性。
对缺血性视网膜进行周边散射激光光凝，新生血管消退。患者开始服用华法林钠以预防进一步血栓形成事件。
对于伊尔斯病患者，尤其是有既往血栓形成事件病史的个体，应在检查中增加包括凝血因子V莱顿突变在内的凝血病实验室评估。
