Franzmann M B, Buchwald C, Jacobsen G K, Lindeberg H
Institute of Pathology, Gentofte University Hospital, Denmark.
Cancer Lett. 1998 Jun 19;128(2):161-4. doi: 10.1016/s0304-3835(98)00058-5.
The aim of the present study was to investigate the expression of p53 in sinonasal papillomas, carcinomas ex papillomas and normal nasal mucosa. Furthermore, we wanted to study the expression of p53 in relation to the presence of human papilloma virus (HPV). Immunohistochemical staining was performed on 37 formalin-fixed paraffin-embedded biopsies comprising seven biopsies from normal nasal mucosa, 13 papillomas of an exophytic growth pattern, 12 papillomas of an endophytic growth pattern and five carcinomas. The level of p53 overexpression was defined as more than 5% positive nuclei. The normal nasal mucosa showed no positive nuclei. The papillomas of both exophytic and endophytic growth patterns showed scattered positive nuclei, but in all cases this was less than 5%. p53 was overexpressed in three out of five carcinomas. In conclusion, we found an overexpression of p53 in carcinomas occurring in sinonasal papillomas but not in the benign tumours of the sinonasal mucosa. Thus, this report supports the concept that p53 may have a role in the carcinogenic process in head and neck tumours.
本研究的目的是调查p53在鼻窦乳头状瘤、乳头状瘤恶变癌及正常鼻黏膜中的表达情况。此外，我们还想研究p53的表达与人类乳头瘤病毒（HPV）存在与否的关系。对37例福尔马林固定石蜡包埋的活检组织进行免疫组化染色，其中包括7例正常鼻黏膜活检组织、13例外生性生长型乳头状瘤、12例内生性生长型乳头状瘤和5例癌组织。p53过表达水平定义为阳性细胞核超过5%。正常鼻黏膜未见阳性细胞核。外生性和内生性生长型乳头状瘤均可见散在的阳性细胞核，但在所有病例中均少于5%。5例癌中有3例p53过表达。总之，我们发现鼻窦乳头状瘤恶变癌中存在p53过表达，而鼻窦黏膜良性肿瘤中未发现。因此，本报告支持p53可能在头颈部肿瘤致癌过程中起作用这一观点。
