Anti M, Pignataro G, Armuzzi A, Valenti A, Iascone E, Marmo R, Lamazza A, Pretaroli A R, Pace V, Leo P, Castelli A, Gasbarrini G
Department of Internal Medicine, Catholic University, Policlinico A. Gemelli, Rome.
Hepatogastroenterology. 1998 May-Jun;45(21):727-32.
BACKGROUND/AIMS: The purpose of this study was to determine the effects of a high-fiber diet and fluid supplementation in patients with functional chronic constipation.
One hundred and seventeen patients with chronic functional constipation (aged 18-50 years) were randomly divided into two treatment groups. For two months both groups consumed a standard diet providing approximately 25 g fiber per day. Group 1 (58 patients) was allowed ad libitum fluid intake, while Group 2 was instructed to drink 2 liters of mineral water per day. Compliance was monitored throughout the study and results were assessed in terms of bowel-movement frequency and laxative use.
Fiber intake was similar in the two groups, while total daily fluid intake in Group 2 (mean 2.1 liters) was significantly greater than that of Group 1 (1.1 liters)(p < 0.001). In both groups, there were statistically significant increases in stool frequency and decreases in laxative use during the two-month trial, but both changes were greater in Group 2 (stool frequency: p < 0.001 vs. Group 1; laxative use: p < 0.001 vs Group 1).
A daily fiber intake of 25 g can increase stool frequency in patients with chronic functional constipation, and this effect can be significantly enhanced by increasing fluid intake to 1.5-2.0 liters/day.
背景/目的:本研究旨在确定高纤维饮食和补充液体对功能性慢性便秘患者的影响。
117例慢性功能性便秘患者(年龄18 - 50岁)被随机分为两个治疗组。两个月内两组均食用提供约25克纤维的标准饮食。第1组(58例患者)可随意饮水,而第2组被指示每天饮用2升矿泉水。在整个研究过程中监测依从性,并根据排便频率和泻药使用情况评估结果。
两组的纤维摄入量相似,而第2组的每日总液体摄入量(平均2.1升)显著高于第1组(1.1升)(p < 0.001)。在两个月的试验期间,两组的排便频率均有统计学显著增加,泻药使用减少,但第2组的这两种变化更大(排便频率:与第1组相比,p < 0.001;泻药使用:与第1组相比,p < 0.001)。
每日摄入25克纤维可增加慢性功能性便秘患者的排便频率,将液体摄入量增加至1.5 - 2.0升/天可显著增强这种效果。