Wang Deng-Chao, Peng Xue-Feng, Chen Wen-Xing, Yu Miao
Department of General Surgery, Zigong Fourth People's Hospital, 19 Tanmulin Road, Zigong, 643000, Sichuan, China.
Department of Basic Medicine, Sichuan Vocational College of Health and Rehabilitation, Zigong, 643000, Sichuan, China.
BMC Public Health. 2025 Jan 31;25(1):399. doi: 10.1186/s12889-025-21346-x.
Constipation is a common gastrointestinal disorder that affects the quality of life of millions of adults worldwide. Dietary moisture intake is considered to have a significant impact on intestinal health, yet its specific role in constipation has not been thoroughly investigated in large-scale population studies. This study aims to explore the correlation between adult dietary moisture intake and constipation by analyzing the NHANES database, filling a knowledge gap in the literature.
Data from NHANES participants aged 20 years and older from 2005 to 2010 were analyzed. Moisture intake was assessed using dietary recall data, which included moisture from all food and beverages consumed. A weighted logistic regression model was used to assess the relationship between moisture intake and the risk of constipation, calculating the odds ratios (ORs) and their 95% confidence intervals (CIs), while controlling for potential confounders. Additionally, restricted cubic splines (RCS) were applied to further explore potential non-linear patterns in the relationship between moisture intake and constipation, along with subgroup analysis.
The study included 14,492 participants, of whom 1,514 reported constipation issues. After adequately adjusting for confounders, a significant negative correlation was observed between moisture intake and constipation risk (OR 0.81; 95% CI: 0.74-0.89). Quartile analysis of moisture intake demonstrated that, compared to the first quartile Q1 (0.06 to 1.90 kg), the constipation risk for the second quartile Q2 (1.91 to 2.53 kg), third quartile Q3 (2.54 to 3.36 kg), and fourth quartile Q4 (3.37 to 16.97 kg) were OR 0.80 (95% CI: 0.64-0.72), OR 0.57 (95% CI: 0.45-0.72), and OR 0.54 (95% CI: 0.44-0.67) respectively, with a trend test P-value ofless than 0.001. RCS regression revealed a significant non-linear negative relationship between moisture intake and constipation prevalence (P < 0.001). Depression may modulate the relationship between moisture and constipation (interaction effect P = 0.014).
The findings of this study indicate that appropriate dietary moisture intake is significantly associated with a lower risk of constipation, demonstrating a dose-response relationship. This emphasizes the importance of considering adequate moisture intake in the prevention and management of constipation. Future studies should adopt a prospective design to further verify the causal relationship between dietary moisture intake and constipation progression.
便秘是一种常见的胃肠道疾病，影响着全球数百万成年人的生活质量。膳食水分摄入被认为对肠道健康有重大影响，但其在便秘中的具体作用尚未在大规模人群研究中得到充分调查。本研究旨在通过分析美国国家健康与营养检查调查（NHANES）数据库，探讨成人膳食水分摄入与便秘之间的相关性，填补文献中的知识空白。
分析了2005年至2010年NHANES中20岁及以上参与者的数据。使用膳食回忆数据评估水分摄入，其中包括所有食用的食物和饮料中的水分。采用加权逻辑回归模型评估水分摄入与便秘风险之间的关系，计算比值比（OR）及其95%置信区间（CI），同时控制潜在的混杂因素。此外，应用受限立方样条（RCS）进一步探索水分摄入与便秘关系中的潜在非线性模式，并进行亚组分析。
该研究纳入了14492名参与者，其中1514人报告有便秘问题。在对混杂因素进行充分调整后，观察到水分摄入与便秘风险之间存在显著的负相关（OR 0.81；95% CI：0.74 - 0.89）。水分摄入的四分位数分析表明，与第一四分位数Q1（0.06至1.90千克）相比，第二四分位数Q2（1.91至2.53千克）、第三四分位数Q3（2.54至3.36千克）和第四四分位数Q4（3.37至16.97千克）的便秘风险分别为OR 0.80（95% CI：0.64 - 0.72）、OR 0.57（95% CI：0.45 - 0.72）和OR 0.54（95% CI：0.44 - 0.67），趋势检验P值小于0.001。RCS回归显示水分摄入与便秘患病率之间存在显著的非线性负相关（P < 0.001）。抑郁可能调节水分与便秘之间的关系（交互作用P = 0.014）。
本研究结果表明，适当的膳食水分摄入与较低的便秘风险显著相关，呈现剂量反应关系。这强调了在便秘的预防和管理中考虑充足水分摄入的重要性。未来的研究应采用前瞻性设计，以进一步验证膳食水分摄入与便秘进展之间的因果关系。
