Calbi M, Giacchetti L
Department of Pediatrics, Villa Bianca Hospital, Naples, Italy.
J Investig Allergol Clin Immunol. 1998 May-Jun;8(3):161-4.
Eosinophil count and IgA breast milk were evaluated at birth in 120 mother-newborn pairs with an 18-month prospective follow-up study. Our study showed a higher risk of developing atopic eczema in newborns with eosinophil count higher than 500 cell/mm3 and with IgA breast milk less than 220 mg/dl (odds ratio 17.6 CI 5.4 to 57.2 p < 0.000086). IgA breast milk is significantly less and eosinophil count is significantly higher at birth in children who develop atopic eczema. This study demonstrates the usefulness of newborn eosinophil count and mother total IgA breast milk level as combined risk factors in the development of atopic eczema in breast-fed babies.
在120对母婴中，于出生时评估嗜酸性粒细胞计数和母乳中的IgA，并进行了为期18个月的前瞻性随访研究。我们的研究表明，嗜酸性粒细胞计数高于500个细胞/mm3且母乳中IgA低于220mg/dl的新生儿患特应性湿疹的风险更高（优势比17.6，可信区间5.4至57.2，p<0.000086）。患特应性湿疹的儿童出生时母乳中IgA显著减少，嗜酸性粒细胞计数显著升高。本研究证明了新生儿嗜酸性粒细胞计数和母亲母乳中总IgA水平作为母乳喂养婴儿患特应性湿疹综合风险因素的有用性。
