Skottová N, Krecman V, Walterová D, Ulrichová J, Kosina P, Simánek V
Institute of Medical Chemistry, Medical Faculty, Palacký University, Olomouc, Czech Republic.
Acta Univ Palacki Olomuc Fac Med. 1998;141:87-9.
Previously we have shown that perorally administered silymarin, a mixture of flavonolignans extracted from the seeds of Silybum marianum, possesses a hypocholesterolemic effect in rats fed high cholesterol diet enriched with fat. The aim of this paper was to complete the data concerning peroral and parenteral administration of silymarin. The rats fed standard laboratory diet did not respond to peroral administration of silymarin by decrease of serum cholesterol, but the mild increase in HDL cholesterol was found. Parenterally injected silymarin failed to reduce serum cholesterol both in rats fed high cholesterol diet and standard laboratory diet. The results suggest that silymarin could act either due to the fat-mediated improved bioavailability and/or by inhibiting of resorption of dietary cholesterol.
此前我们已经表明，经口给予水飞蓟素（一种从水飞蓟种子中提取的黄酮木脂素混合物），对喂食富含脂肪的高胆固醇饮食的大鼠具有降胆固醇作用。本文的目的是完善有关水飞蓟素经口和非经口给药的数据。喂食标准实验室饮食的大鼠，经口给予水飞蓟素后血清胆固醇未降低，但发现高密度脂蛋白胆固醇有轻度升高。无论是喂食高胆固醇饮食还是标准实验室饮食的大鼠，非经口注射水飞蓟素均未能降低血清胆固醇。结果表明，水飞蓟素可能是由于脂肪介导的生物利用度提高和/或通过抑制膳食胆固醇的吸收而起作用。
