Polman K, Engels D, Fathers L, Deelder A M, Gryseels B
Department of Parasitology, University of Leiden, The Netherlands.
Am J Trop Med Hyg. 1998 Jul;59(1):150-4. doi: 10.4269/ajtmh.1998.59.150.
Day-to-day fluctuations of both circulating anodic antigen (CAA) and circulating cathodic antigen (CCA) in serum and urine were examined simultaneously in a group of Schistosoma mansoni-infected individuals from Burundi and compared with each other and with fecal egg count fluctuations. Significant correlations were found between fecal egg counts and circulating antigens (CAA and CCA) and between circulating antigen levels in serum and urine samples. The cumulative percentage of positive results after three samplings was highest for urine CCA detection, followed by fecal egg counts, serum CCA, serum CAA, and urine CAA detection, respectively. It was demonstrated that circulating antigen levels in both serum and urine showed less fluctuation than fecal egg counts, except for urine CAA levels. The serum CAA detection assay in particular, although less sensitive in this low endemic area in Burundi, gave very constant measurements over a period of one week. Our results indicate that detection of circulating antigens in a single serum or urine sample provides a quantitatively more stable diagnosis of S. mansoni infection than fecal egg counts based on a single stool examination.
在一组来自布隆迪的曼氏血吸虫感染个体中，同时检测了血清和尿液中循环阳极抗原（CAA）和循环阴极抗原（CCA）的每日波动情况，并将它们相互比较，同时与粪便虫卵计数波动情况进行比较。结果发现，粪便虫卵计数与循环抗原（CAA和CCA）之间以及血清和尿液样本中的循环抗原水平之间存在显著相关性。三次采样后阳性结果的累积百分比，尿液CCA检测最高，其次分别是粪便虫卵计数、血清CCA、血清CAA和尿液CAA检测。结果表明，除尿液CAA水平外，血清和尿液中的循环抗原水平波动均小于粪便虫卵计数。特别是血清CAA检测方法，尽管在布隆迪这个低流行地区敏感性较低，但在一周的时间内测量结果非常稳定。我们的结果表明，与基于单次粪便检查的粪便虫卵计数相比，检测单个血清或尿液样本中的循环抗原能提供对曼氏血吸虫感染更定量稳定的诊断。
