Nosé Y
Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.
Artif Organs. 1998 Jul;22(7):618-22. doi: 10.1046/j.1525-1594.1998.06203.x.
A stabilized form of hemoglobin as oxygen-carrying macromolecules was developed. It had an approximately 90,000 dalton molecular weight, and its intravascular half-life was 36 h. Its molecular size was less than 0.1 microm. Its hemoglobin concentration was 6% and its P50 value was 24 mm Hg. Oxygen carried inside plasma performs differently than oxygen carried inside red cells. Less than 0.3 cc of oxygen in 100 ml of blood is available in the plasma while 14-19 ml of oxygen is carried inside the red cells. Thus, less than 5 cc of oxygen is available inside the plasma of the entire body. When a patient develops hypovolemic shock, the red cells are bypassed and are not perfused directly inside the tissues. However, the plasma should reach hypoxic tissues. Thus, infusion of oxygen-carrying macromolecules into the plasma should be therapeutically effective even when infusing less than 100 ml of stabilized hemoglobin solution under shock conditions. The basic physiology of oxygen-carrying macromolecules is described in detail, which is different from the physiology of oxygen-carrying red cells.
开发出了一种作为携氧大分子的稳定形式的血红蛋白。它的分子量约为90,000道尔顿，其血管内半衰期为36小时。其分子大小小于0.1微米。其血红蛋白浓度为6%，P50值为24毫米汞柱。血浆中携带的氧气与红细胞内携带的氧气表现不同。每100毫升血液中血浆所含的氧气不到0.3立方厘米，而红细胞内携带14 - 19毫升氧气。因此，整个身体的血浆中所含氧气不到5立方厘米。当患者发生低血容量性休克时，红细胞会被绕过，不会直接在组织内得到灌注。然而，血浆应能到达缺氧组织。因此，即使在休克状态下输注不到100毫升稳定化血红蛋白溶液，向血浆中输注携氧大分子也应具有治疗效果。详细描述了携氧大分子的基本生理学，它与携氧红细胞的生理学不同。
