一种高产甲型流感病毒重组体的基因组成：一种针对“猪”流感的疫苗株
Genetic composition of a high-yielding influenza A virus recombinant: a vaccine strain against "Swine" influenza.
作者信息
Palese P, Ritchey M B, Schulman J L, Kilbourne E D
出版信息
Science. 1976 Oct 15;194(4262):334-5. doi: 10.1126/science.968486.
PMID:968486
Abstract
Analysis of the RNA migration pattern of a high-yielding influenza virus recombinant, X-53, used in vaccine production, reveals that only the two genes coding for hemagglutinin and neuraminidase antigens were derived from the "swine" influenza virus parent. A/New Jersey/11/76, while six were acquired from the A/PR/8/34 (HON1) parent, donor of the high yield characteristic.
摘要
对用于疫苗生产的高产流感病毒重组体X-53的RNA迁移模式分析表明，仅编码血凝素和神经氨酸酶抗原的两个基因源自“猪”流感病毒亲本A/新泽西/11/76，而另外六个基因则来自高产特性供体A/PR/8/34（H1N1）亲本。
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