Qureshi S N, Shakoori A R
Department of Zoology, University of the Punjab, Lahore, Pakistan.
J Appl Toxicol. 1998 May-Jun;18(3):167-71. doi: 10.1002/(sici)1099-1263(199805/06)18:3<167::aid-jat492>3.0.co;2-8.
The embryotoxic and teratogenic potential of hexavalent chromium was evaluated in chick embryos. Different concentrations of aqueous solution of potassium dichromate ranging from 1.00 to 100.00 microg per egg were injected into chick eggs before incubation. A dose-dependent embryonic mortality was observed in all the groups examined on days 7 and 14 of incubation. The following malformations were observed in survivors: reduced body size and organs; microphthalmia; micromelia; everted viscera; abnormal and twisted neck, beak and spinal cord; isolated epicarditis; club foot; haemorrhage; and patchy feathers. Total mortality showing embryonic resorption was noted in higher dose groups (25-100 microg per egg) on day 14 of incubation.
在鸡胚中评估了六价铬的胚胎毒性和致畸潜力。在孵化前，将浓度范围为每枚鸡蛋1.00至100.00微克的重铬酸钾水溶液注入鸡蛋。在孵化的第7天和第14天，在所有检测组中均观察到剂量依赖性胚胎死亡。在存活者中观察到以下畸形：体型和器官缩小；小眼症；短肢畸形；内脏外翻；颈部、喙和脊髓异常扭曲；孤立性心外膜炎；马蹄内翻足；出血；以及羽毛斑驳。在孵化第14天，较高剂量组（每枚鸡蛋25 - 100微克）出现了显示胚胎吸收的总死亡率。
