Ling C, Schneider G E, Jhaveri S
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA.
Vis Neurosci. 1998 May-Jun;15(3):559-79. doi: 10.1017/s0952523898153178.
The B fragment of cholera toxin (CT-B) provides a highly sensitive anterograde tracer for labeling retinofugal axons, revealing dense projections to known central retinorecipient nuclei, and sparse but distinct inputs to regions that have not been traditionally recognized as targets of direct retinal projections. In hamsters, we can identify CT-B labeled retinal axons in more than 25 cell groups in the mesencephalon, diencephalon, and basal telencephalon. CT-B labeling additionally delineates the complete arbor morphology, especially in regions that receive a sparse input, offering hitherto unknown views of retinal axon ramifications. We present here the terminal morphology of retinal axons in the lateral geniculate body and superior colliculus, verifying earlier studies, and also document novel findings on the configuration of retinal axon endings in the ventral nucleus of the lateral geniculate body, intergeniculate leaflet, suprachiasmatic nucleus, and in the nuclei of the accessory optic tract. Additionally, the trajectory and terminal morphology of retinal afferents to the hypothalamus, preoptic area, and basal telencephalon are detailed. The results are discussed in the context of possible functional roles for some of these projections.
霍乱毒素B片段（CT-B）是一种高度敏感的顺行示踪剂，可用于标记视网膜传出轴突，揭示其向已知的中枢视网膜接受核的密集投射，以及向传统上未被视为直接视网膜投射靶点区域的稀疏但独特的输入。在仓鼠中，我们可以在中脑、间脑和基底前脑的25多个细胞群中识别出CT-B标记的视网膜轴突。CT-B标记还描绘了完整的树突形态，特别是在接受稀疏输入的区域，提供了迄今未知的视网膜轴突分支视图。我们在此展示了外侧膝状体和上丘中视网膜轴突的终末形态，证实了早期研究，并记录了外侧膝状体腹侧核、膝间小叶、视交叉上核以及副视束核中视网膜轴突终末构型的新发现。此外，还详细描述了视网膜传入纤维至下丘脑、视前区和基底前脑的轨迹和终末形态。并结合其中一些投射可能的功能作用对结果进行了讨论。
