Iza M, Stoianovici G, Viora L, Grossiord J L, Couarraze G
Laboratoire de Physique Pharmaceutique, URA CNRS 1218, Faculté de Pharmacie, Université Paris-Sud, Chatenay-Malabry, France.
J Control Release. 1998 Mar 2;52(1-2):41-51. doi: 10.1016/s0168-3659(97)00191-0.
Thermosensitive polymer networks were synthesized from poly(ethylene glycol), hexamethylene diisocyanate and 1,2,6-hexanetriol in stoichiometric proportions. By varying the amount of 1,2,6-hexanetriol and the molar mass of the poly(ethylene glycol), a wide range of networks with different crosslinking densities was prepared. The networks obtained were characterized by the temperature dependence of their degree of equilibrium swelling in water and by their Young's moduli. For each network, the molecular weight between crosslinks was estimated. The structure of the hydrogels was analysed with respect to scaling laws, and it was found that the results obtained with PEG 1500 and PEG 6000 hydrogels are in agreement with theoretical predictions, whereas those obtained with PEG 400 hydrogels are in disagreement. The release properties of PEG hydrogels were studied by the determination of the diffusion coefficient for acebutolol chlorhydrate and by an analysis of the effect of temperature on these coefficients. Finally, these release properties were correlated with the swelling and structural properties of the hydrogels.
热敏聚合物网络由聚乙二醇、六亚甲基二异氰酸酯和1,2,6 -己三醇按化学计量比合成。通过改变1,2,6 -己三醇的用量和聚乙二醇的摩尔质量，制备了一系列具有不同交联密度的网络。所得到的网络通过其在水中平衡溶胀度的温度依赖性及其杨氏模量进行表征。对于每个网络，估算了交联点之间的分子量。根据标度律分析了水凝胶的结构，发现用PEG 1500和PEG 6000水凝胶得到的结果与理论预测一致，而用PEG 400水凝胶得到的结果不一致。通过测定盐酸醋丁洛尔的扩散系数并分析温度对这些系数的影响，研究了PEG水凝胶的释放性能。最后，将这些释放性能与水凝胶的溶胀和结构性能相关联。
