Léger F, Callens A, Machet M C
Service de dermatologie, CHU de Tours.
Ann Dermatol Venereol. 1997;124(3):257-9.
Parvovirus B19 infection is frequent. Primary infection leads to diverse skin manifestations including the recently described gloves-and-socks papulopurpura.
A patient presented with a papulopurpuric eruption on the nose, hands, feet and perineum with cheilitis and high-grade fever. Parvovirus B19 serology showed characteristic IgG on the 15th day after the initial eruption demonstrating the seroconversion. Cold agglutinins were positive during the eruption and negative after regression.
The gloves-and-socks papulopurpura syndrome was initially described in 1990. Since that time 20 cases have been reported. In 7 cases, primary parvovirus B19 infection was proven and viral infections were suspected in the others (measles, coxsackie B6, hepatitis B, Epstein-Barr virus). Our case evidenced here to undescribed skin manifestations and the development of cold agglutinins. The presence of cold agglutinins at eruption could explain the acral localizations observed in this syndrome.
细小病毒B19感染很常见。初次感染会导致多种皮肤表现，包括最近描述的手套 - 袜子样丘疹紫癜。
一名患者出现鼻子、手、脚和会阴部的丘疹紫癜疹，伴有唇炎和高热。细小病毒B19血清学检查显示，初发皮疹后第15天出现特征性IgG，表明血清转化。皮疹发作期间冷凝集素呈阳性，消退后呈阴性。
手套 - 袜子样丘疹紫癜综合征最初于1990年被描述。自那时以来，已报告20例。其中7例证实为初次细小病毒B19感染，其他病例怀疑为病毒感染（麻疹、柯萨奇B6病毒、乙型肝炎病毒、爱泼斯坦 - 巴尔病毒）。我们在此报告的病例出现了未描述的皮肤表现以及冷凝集素的产生。皮疹发作时冷凝集素的存在可以解释该综合征中观察到的肢端定位。
