Woerly S, Pinet E, De Robertis L, Bousmina M, Laroche G, Roitback T, Vargová L, Syková E
Organogel Canada Ltd, Quebec City, Quebec, Canada.
J Biomater Sci Polym Ed. 1998;9(7):681-711. doi: 10.1163/156856298x00091.
A biocompatible heterogeneous hydrogel of poly[N-(2-hydroxypropyl) methacrylamide] (PHPMA) showing an open porous structure, viscoelastic properties similar to the neural tissue and a large surface area available for cell interaction, was evaluated for its ability to promote tissue repair and axonal regeneration in the transected rat spinal cord. After implantation, the polymer hydrogel could correctly bridge the tissue defect, from a permissive interface with the host tissue to favour cell ingrowth, angiogenesis and axonal growth occurred within the microstructure of the network. Within 3 months the polymer implant was invaded by host derived tissue, glial cells, blood vessels and axons penetrated the hydrogel implant. Such polymer hydrogel matrices which show neuroinductive and neuroconductive properties have the potential to repair tissue defects in the central nervous system by promoting the formation of a tissue matrix and axonal growth by replacing the lost of tissue.
聚N-(2-羟丙基)甲基丙烯酰胺的一种生物相容性异质水凝胶，具有开放的多孔结构、类似于神经组织的粘弹性特性以及可用于细胞相互作用的大表面积，对其促进横断大鼠脊髓组织修复和轴突再生的能力进行了评估。植入后，聚合物水凝胶能够正确地桥接组织缺损，从与宿主组织的许可界面有利于细胞向内生长，血管生成和轴突生长发生在网络的微观结构内。在3个月内，聚合物植入物被宿主来源的组织侵入，胶质细胞、血管和轴突穿透水凝胶植入物。这种具有神经诱导和神经传导特性的聚合物水凝胶基质有潜力通过促进组织基质的形成和通过替代丢失的组织来促进轴突生长，从而修复中枢神经系统的组织缺损。
