Wei Y T, Tian W M, Yu X, Cui F Z, Hou S P, Xu Q Y, Lee In-Seop
Biomaterials Laboratory, Department of Materials Science & Engineering, Tsinghua University, Beijing, 100084, People's Republic of China.
Biomed Mater. 2007 Sep;2(3):S142-6. doi: 10.1088/1748-6041/2/3/S11. Epub 2007 Jul 30.
A biocompatible hydrogel of hyaluronic acid with the neurite-promoting peptide sequence of IKVAV was synthesized. The characterization of the hydrogel shows an open porous structure and a large surface area available for cell interaction. Its ability to promote tissue repair and axonal regeneration in the lesioned rat cerebrum is also evaluated. After implantation, the polymer hydrogel repaired the tissue defect and formed a permissive interface with the host tissue. Axonal growth occurred within the microstructure of the network. Within 6 weeks the polymer implant was invaded by host-derived tissue, glial cells, blood vessels and axons. Such a hydrogel matrix showed the properties of neuron conduction. It has the potential to repair tissue defects in the central nervous system by promoting the formation of a tissue matrix and axonal growth by replacing the lost tissue.
合成了一种具有IKVAV促神经突生长肽序列的透明质酸生物相容性水凝胶。水凝胶的表征显示出开放的多孔结构和可用于细胞相互作用的大表面积。还评估了其促进损伤大鼠大脑组织修复和轴突再生的能力。植入后，聚合物水凝胶修复了组织缺损并与宿主组织形成了允许性界面。轴突在网络的微观结构内生长。6周内，聚合物植入物被宿主来源的组织、胶质细胞、血管和轴突侵入。这种水凝胶基质显示出神经元传导的特性。它有潜力通过促进组织基质的形成和通过替代丢失的组织来促进轴突生长，从而修复中枢神经系统的组织缺损。
