McCaul M E
Johns Hopkins University School of Medicine, Johns Hopkins Hospital Comprehensive Women's Center, Baltimore, MD 21205, USA.
NIDA Res Monogr. 1998 Mar;169:188-208.
Epidemiological research has clearly demonstrated the importance of a family history as a determinant of future alcohol and, possibly, drug use in offspring of alcoholics. Laboratory studies have examined a wide range of potential markers both in the presence and absence of alcohol challenge, which may predict those subjects at high risk for the future development of alcoholism. While this body of research has yielded several replicable differences in FHP and FHN subjects, it also has been marked by many discrepancies in outcomes across studies. Future refinements in subject ascertainment and laboratory methodologies may help to bring greater procedural uniformity and consistency in study outcomes.
流行病学研究已清楚地证明家族病史作为酗酒者后代未来饮酒以及可能吸毒的一个决定因素的重要性。实验室研究已在有和没有酒精激发试验的情况下检测了一系列潜在标志物，这些标志物可能预测那些未来有酗酒高风险的受试者。虽然这一系列研究在FHP和FHN受试者中产生了一些可重复的差异，但研究结果在不同研究中也存在许多差异。未来在受试者确定和实验室方法方面的改进可能有助于在研究结果中实现更大的程序一致性和连贯性。
