Yesavage J A, Friedman L, Kraemer H C, Noda A, Wicks D, Bliwise D L, Sheikh J, Tinklenberg J, Zarcone V
Department of Veterans Affairs Medical Center, Stanford University, Palo Alto, California 94304, USA.
J Geriatr Psychiatry Neurol. 1998 Spring;11(1):7-10. doi: 10.1177/089198879801100103.
This article reports cross-sectional and follow-up data with actigraphic measures of nocturnal sleep and rest/activity in 61 Alzheimer's disease (AD) patients as well as the relation of actigraphic measures to levels of behavioral disturbance across different stages of the disease. Over the course of approximately 1.5 years' follow-up, patients showed significant deterioration of nocturnal sleep parameters, but no significant change in rest/activity circadian rhythm parameters. There were also significant correlations among nocturnal sleep, rest/activity circadian rhythm, and behavioral disturbance measures, but only in relatively early stages of AD. It is argued that study of nocturnal sleep and circadian rhythm in relation to behavioral disturbance in AD requires longitudinal data and analyses that take into account the stage of disease at which patients are assessed.
本文报告了61例阿尔茨海默病（AD）患者夜间睡眠及休息/活动的体动记录仪测量的横断面和随访数据，以及体动记录仪测量结果与疾病不同阶段行为障碍水平之间的关系。在大约1.5年的随访过程中，患者夜间睡眠参数显著恶化，但休息/活动昼夜节律参数无显著变化。夜间睡眠、休息/活动昼夜节律和行为障碍测量之间也存在显著相关性，但仅在AD相对早期阶段。有人认为，研究AD中与行为障碍相关的夜间睡眠和昼夜节律需要纵向数据和分析，并考虑到评估患者时的疾病阶段。
