Neuhuber W L, Kressel M, Stark A, Berthoud H R
Anatomy Institute, University of Erlangen-Nürnberg, Erlangen, Germany.
J Auton Nerv Syst. 1998 May 28;70(1-2):92-102. doi: 10.1016/s0165-1838(98)00034-4.
Anterograde tracing with the carbocyanine tracer DiI and the aminostyrol derivative DiA was used to selectively label fibers from the nucleus ambiguus, dorsal motor nucleus and nodose ganglion, respectively, terminating in the rat esophagus, and to compare them with the innervation of the gastric fundus in the same animals. Ambiguus neurons terminated on motor endplates distributed mainly to the ipsilateral half of the esophagus. There was no evidence of preganglionic innervation of myenteric ganglia from ambiguus neurons. Neurons of the dorsal motor nucleus supplied sparse fibers to only about 10% of enteric ganglia in the esophagus while they innervated up to 100% of myenteric ganglia in the stomach. Neurons of the nodose ganglion terminated profusely on more than 90% of myenteric ganglia of the esophagus and on about 50% of ganglia in the stomach. Afferent vagal fibers were also frequently found in smooth muscle layers starting at the esophago-gastric junction. In contrast, they were extremely rare in the striated muscle part of the esophagus. These morphological data suggest a minor influence of neurons of the dorsal motor nucleus and a prominent influence of vagal afferent terminals onto myenteric neurons in the rat esophagus.
使用碳青霉烯类示踪剂DiI和氨基苯乙烯衍生物DiA进行顺行示踪，分别选择性标记来自疑核、迷走神经背核和结状神经节并终止于大鼠食管的纤维，并将它们与同一动物胃底的神经支配进行比较。疑核神经元终止于主要分布在食管同侧半侧的运动终板上。没有证据表明疑核神经元对肠肌神经节有节前神经支配。迷走神经背核的神经元仅向食管中约10%的肠神经节提供稀疏纤维，而它们支配胃中高达100%的肠肌神经节。结状神经节的神经元大量终止于食管中超过90%的肠肌神经节和胃中约50%的神经节上。在食管-胃交界处开始的平滑肌层中也经常发现迷走传入纤维。相比之下，它们在食管的横纹肌部分极为罕见。这些形态学数据表明，迷走神经背核的神经元对大鼠食管中肠肌神经元的影响较小，而迷走传入终末的影响显著。
