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酮内酯类药物HMR 3647对近期革兰氏阳性临床分离株和流感嗜血杆菌的体外活性。

In vitro activities of the ketolide HMR 3647 against recent gram-positive clinical isolates and Haemophilus influenzae.

作者信息

Barry A L, Fuchs P C, Brown S D

机构信息

The Clinical Microbiology Institute, Wilsonville, Oregon 97070, USA.

出版信息

Antimicrob Agents Chemother. 1998 Aug;42(8):2138-40. doi: 10.1128/AAC.42.8.2138.

DOI:10.1128/AAC.42.8.2138
PMID:9687424
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105887/
Abstract

The ketolide HMR 3647 (previously RU 66647) was evaluated against 2, 563 recent clinical isolates of gram-positive pathogens and 200 Haemophilus influenzae isolates. HMR 3647 was active against macrolide-resistant streptococci, including pneumococci, but was not active against macrolide- or lincosamide-resistant staphylococci. Against H. influenzae, the potency of HMR 3647 was similar to that of azithromycin.

摘要

对酮内酯类药物HMR 3647（以前称为RU 66647）针对2563株近期临床分离的革兰氏阳性病原体和200株流感嗜血杆菌分离株进行了评估。HMR 3647对大环内酯类耐药链球菌，包括肺炎球菌有活性，但对大环内酯类或林可酰胺类耐药葡萄球菌无活性。对于流感嗜血杆菌，HMR 3647的效力与阿奇霉素相似。

相似文献

1
In vitro activities of the ketolide HMR 3647 against recent gram-positive clinical isolates and Haemophilus influenzae.酮内酯类药物HMR 3647对近期革兰氏阳性临床分离株和流感嗜血杆菌的体外活性。
Antimicrob Agents Chemother. 1998 Aug;42(8):2138-40. doi: 10.1128/AAC.42.8.2138.
2
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本文引用的文献

1
Antipneumococcal activities of a ketolide (HMR 3647), a streptogramin (quinupristin-dalfopristin), a macrolide (erythromycin), and a lincosamide (clindamycin).一种酮内酯（HMR 3647）、一种链阳菌素（奎奴普丁-达福普汀）、一种大环内酯（红霉素）和一种林可酰胺（克林霉素）的抗肺炎球菌活性。
Antimicrob Agents Chemother. 1998 Apr;42(4):945-6. doi: 10.1128/AAC.42.4.945.
2
In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae.新型酮内酯类药物HMR 3004与氮杂内酯类和大环内酯类药物相比，对肺炎链球菌和流感嗜血杆菌的体外活性。
Eur J Clin Microbiol Infect Dis. 1997 Oct;16(10):767-9. doi: 10.1007/BF01709263.
3
Antibacterial activity of RU 64004 (HMR 3004), a novel ketolide derivative active against respiratory pathogens.新型酮内酯衍生物RU 64004（HMR 3004）对呼吸道病原体的抗菌活性
Antimicrob Agents Chemother. 1997 Oct;41(10):2149-58. doi: 10.1128/AAC.41.10.2149.
4
Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004).酮内酯类药物HMR 3647（RU 66647）和HMR 3004（RU 64004）的抗厌氧活性比较
Antimicrob Agents Chemother. 1997 Sep;41(9):2019-22. doi: 10.1128/AAC.41.9.2019.
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J Antimicrob Chemother. 1997 Jul;40(1):139-40. doi: 10.1093/jac/40.1.139.
6
In vitro activity of RU 64004, a new ketolide antibiotic, against gram-positive bacteria.新型酮内酯类抗生素RU 64004对革兰氏阳性菌的体外活性
Antimicrob Agents Chemother. 1997 May;41(5):1196-202. doi: 10.1128/AAC.41.5.1196.
7
Antimicrobial activity of RU-66647, a new ketolide.新型酮内酯RU-66647的抗菌活性
Diagn Microbiol Infect Dis. 1997 Jan-Feb;27(1-2):7-12. doi: 10.1016/s0732-8893(96)00181-2.
8
In vitro evaluation of a novel ketolide antimicrobial agent, RU-64004.新型酮内酯类抗菌剂RU-64004的体外评价
Antimicrob Agents Chemother. 1997 Feb;41(2):454-9. doi: 10.1128/AAC.41.2.454.