一种酮内酯（HMR 3647）、一种链阳菌素（奎奴普丁-达福普汀）、一种大环内酯（红霉素）和一种林可酰胺（克林霉素）的抗肺炎球菌活性。
Antipneumococcal activities of a ketolide (HMR 3647), a streptogramin (quinupristin-dalfopristin), a macrolide (erythromycin), and a lincosamide (clindamycin).
作者信息
Barry A L, Fuchs P C, Brown S D
机构信息
The Clinical Microbiology Institute, Wilsonville, Oregon 97070, USA.
出版信息
Antimicrob Agents Chemother. 1998 Apr;42(4):945-6. doi: 10.1128/AAC.42.4.945.
Abstract
Four different compounds belonging to the macrolide-lincosamide-streptogramin B (MLSb) class of antimicrobial agents were tested against 611 Streptococcus pneumoniae strains. The ketolide (HMR 3647, previously RU66647) and the streptogramin (quinupristin-dalfopristin) were both active against pneumococci with high-level MLSb resistance (clindamycin-resistant strains) as well as those with low-level macrolide resistance (clindamycin-susceptible strains).
摘要
针对611株肺炎链球菌，测试了四种属于大环内酯-林可酰胺-链阳菌素B（MLSb）类抗菌剂的不同化合物。酮内酯（HMR 3647，先前为RU66647）和链阳菌素（奎奴普丁-达福普汀）对具有高水平MLSb耐药性（克林霉素耐药菌株）以及低水平大环内酯耐药性（克林霉素敏感菌株）的肺炎球菌均有活性。
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