Barry A L, Fuchs P C, Brown S D
The Clinical Microbiology Institute, Wilsonville, Oregon 97070, USA.
Antimicrob Agents Chemother. 1998 Apr;42(4):945-6. doi: 10.1128/AAC.42.4.945.
Four different compounds belonging to the macrolide-lincosamide-streptogramin B (MLSb) class of antimicrobial agents were tested against 611 Streptococcus pneumoniae strains. The ketolide (HMR 3647, previously RU66647) and the streptogramin (quinupristin-dalfopristin) were both active against pneumococci with high-level MLSb resistance (clindamycin-resistant strains) as well as those with low-level macrolide resistance (clindamycin-susceptible strains).
针对611株肺炎链球菌,测试了四种属于大环内酯-林可酰胺-链阳菌素B(MLSb)类抗菌剂的不同化合物。酮内酯(HMR 3647,先前为RU66647)和链阳菌素(奎奴普丁-达福普汀)对具有高水平MLSb耐药性(克林霉素耐药菌株)以及低水平大环内酯耐药性(克林霉素敏感菌株)的肺炎球菌均有活性。