来自18S rRNA基因分析的确证证据，用于研究一名患者眼部棘阿米巴分离株时间序列中喷他脒抗性的体内发展情况。
Confirmatory evidence from 18S rRNA gene analysis for in vivo development of propamidine resistance in a temporal series of Acanthamoeba ocular isolates from a patient.
作者信息
Ledee D R, Seal D V, Byers T J
机构信息
Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA.
出版信息
Antimicrob Agents Chemother. 1998 Aug;42(8):2144-5. doi: 10.1128/AAC.42.8.2144.
Abstract
DNA sequences of three 18S rRNA gene alleles present in trophozoites obtained before and after therapy for Acanthamoeba keratitis substantiate a previous report that the infection was due to a single Acanthamoeba strain. Thus, the possibility that propamidine resistance which developed during therapy was due to a mixed infection was ruled out.
摘要
在棘阿米巴角膜炎治疗前后获取的滋养体中存在的三种18S rRNA基因等位基因的DNA序列证实了先前的一份报告，即该感染是由单一棘阿米巴菌株引起的。因此，治疗期间出现的丙脒耐药性是由于混合感染所致的可能性被排除。
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