Wright P, Warhurst D, Jones B R
Br J Ophthalmol. 1985 Oct;69(10):778-82. doi: 10.1136/bjo.69.10.778.
The first medical cure of a corneal infection due to an Acanthamoeba species is reported. The 44-year-old patient developed a suppurative keratitis associated with an epithelial defect, hypopyon, and secondary glaucoma. Acanthamoeba was confirmed as the causative agent four months after presentation when positive cultures were obtained from the cornea and from the conjunctiva. Sensitivity studies of the isolated organism were performed, and the infection was successfully controlled by treatment with a combination of dibromopropamidine and propamidine isethionate ointment and drops and neomycin drops. Keratoplasty was performed 22 months after onset, and no viable acanthamoebae were present in the resected tissue, though possible cyst remnants were identified by immunofluorescent techniques.
据报道，首例因棘阿米巴属物种引起的角膜感染得到了医学治愈。该44岁患者出现了化脓性角膜炎，伴有上皮缺损、前房积脓和继发性青光眼。就诊四个月后，从角膜和结膜获得阳性培养物，确诊棘阿米巴为病原体。对分离出的病原体进行了敏感性研究，通过联合使用双溴丙脒、羟乙磺酸丙脒软膏和滴眼液以及新霉素滴眼液进行治疗，感染得到了成功控制。发病22个月后进行了角膜移植术，切除的组织中未发现存活的棘阿米巴，但通过免疫荧光技术鉴定出可能的囊肿残余物。
