Lewandowski K, Busch T, Lohbrunner H, Rensing S, Keske U, Gerlach H, Falke K J
Klinik für Anästhesiologie und operative Intensivmedizin, D-13353 Berlin, Germany.
J Appl Physiol (1985). 1998 Aug;85(2):405-10. doi: 10.1152/jappl.1998.85.2.405.
To investigate whether relevant levels of nasal nitric oxide (NO) are produced in the absence of paranasal sinuses, we studied 17 healthy baboons, mammals without any paranasal sinuses. The animals were anesthetized with ketamine hydrochloride and breathed spontaneously. While the baboons breathed through a face mask (mouths closed) connected to a respirator, NO concentrations in exhaled gas were sampled from the expiratory limb and analyzed by chemiluminescence. While the animals were breathing ambient air, nasal gas was sampled via a thin plastic tube and analyzed for NO concentrations by chemiluminescence. Mean NO concentration in the exhaled gas was 1.00 +/- 0.59 parts/billion, and NO release was 4.28 +/- 2.72 nl/min. A NO concentration of 4.79 +/- 2.08 parts/billion was found in the nasal gas (NO release: 7.18 +/- 3.13 nl/min). An age-dependent increase in nasal NO levels was not observed. Exhaled and nasal NO concentrations in baboons were markedly lower than in mammals with paranasal sinuses, suggesting that paranasal sinuses might be an anatomic requirement for production of relevant nasal NO levels.
为了研究在没有鼻窦的情况下是否会产生相关水平的鼻腔一氧化氮（NO），我们对17只健康的狒狒进行了研究，狒狒是没有任何鼻窦的哺乳动物。动物用盐酸氯胺酮麻醉并自主呼吸。当狒狒通过连接到呼吸器的面罩（嘴闭合）呼吸时，从呼气支路采集呼出气体中的NO浓度，并通过化学发光法进行分析。当动物呼吸环境空气时，通过细塑料管采集鼻腔气体，并通过化学发光法分析NO浓度。呼出气体中的平均NO浓度为1.00±0.59十亿分之一，NO释放量为4.28±2.72纳升/分钟。鼻腔气体中的NO浓度为4.79±2.08十亿分之一（NO释放量：7.18±3.13纳升/分钟）。未观察到鼻腔NO水平随年龄增长而增加。狒狒呼出和鼻腔的NO浓度明显低于有鼻窦的哺乳动物，这表明鼻窦可能是产生相关鼻腔NO水平的解剖学条件。
