JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?
作者信息
Karin M, Delhase M
机构信息
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9067-9. doi: 10.1073/pnas.95.16.9067.
Abstract
摘要
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JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?JNK 或 IKK，AP-1 或核因子κB，哪些是丝裂原活化蛋白激酶激酶 1 的作用靶点？
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本文引用的文献
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NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation.核因子κB诱导激酶和IκB激酶参与人类T细胞白血病病毒I型Tax介导的核因子κB激活。
J Biol Chem. 1998 Aug 14;273(33):21132-6. doi: 10.1074/jbc.273.33.21132.
2
MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.丝裂原活化蛋白激酶激酶1激活IκB激酶α和IκB激酶β。
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9319-24. doi: 10.1073/pnas.95.16.9319.
3
HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.人嗜T淋巴细胞病毒I型Tax蛋白与丝裂原活化蛋白激酶激酶激酶1结合，以刺激IκB激酶活性和核因子κB激活。
Cell. 1998 May 29;93(5):875-84. doi: 10.1016/s0092-8674(00)81447-6.
4
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal.死亡结构域激酶RIP介导肿瘤坏死因子诱导的核因子κB信号。
Immunity. 1998 Mar;8(3):297-303. doi: 10.1016/s1074-7613(00)80535-x.
5
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.核因子-κB诱导激酶通过磷酸化丝氨酸176激活IKK-α。
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3792-7. doi: 10.1073/pnas.95.7.3792.
6
Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.两种上游激酶，即核因子κB诱导激酶和丝裂原活化蛋白激酶/细胞外信号调节激酶激酶激酶-1对IkappaB激酶α和β的差异调节
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3537-42. doi: 10.1073/pnas.95.7.3537.
7
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.TRAF2基因缺陷型小鼠的早期致死性、功能性核因子κB激活以及对肿瘤坏死因子诱导的细胞死亡敏感性增加。
Immunity. 1997 Nov;7(5):715-25. doi: 10.1016/s1074-7613(00)80391-x.
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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.核因子κB抑制蛋白激酶β：核因子κB激活以及与核因子κB抑制蛋白激酶α和NF-κB诱导激酶形成复合物
Science. 1997 Oct 31;278(5339):866-9. doi: 10.1126/science.278.5339.866.
9
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.IKK-1和IKK-2：细胞因子激活的IkappaB激酶，对NF-kappaB激活至关重要。
Science. 1997 Oct 31;278(5339):860-6. doi: 10.1126/science.278.5339.860.
10
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.IκB激酶复合物（IKK）包含两个激酶亚基，即IKKα和IKKβ，它们是IκB磷酸化和NF-κB激活所必需的。
Cell. 1997 Oct 17;91(2):243-52. doi: 10.1016/s0092-8674(00)80406-7.
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