通过检测病毒基因组和E2抗体确定斯洛文尼亚血液透析患者中庚型肝炎病毒感染的患病率。

Prevalence of hepatitis G virus infection in Slovenian hemodialysis patients as determined by the detection of viral genome and E2 antibodies.

作者信息

Seme K, Poljak M, Jeverica S, Koren A, Sasa Zuzek-Resek S

机构信息

Institute of Microbiology and Immunology, Medical Faculty of Ljubljana, Slovenia.

出版信息

Nephron. 1998 Aug;79(4):426-9. doi: 10.1159/000045088.

DOI:10.1159/000045088

PMID:9689158

Abstract

The prevalence of hepatitis G virus (HGV) infection was assessed by the detection of viral genome and HGV E2 antibodies in hemodialysis patients from a dialysis unit with the highest prevalence of hepatitis C virus infection in Slovenia. HGV RNA was detected in 7 (11.9%) and HGV E2 antibodies in 20 (33.9%) of 59 hemodialysis patients. One patient had detectable HGV RNA as well as HGV E2 antibodies in her serum sample at the time of the study. The total prevalence of HGV infection was 44.1%. Our results clearly indicate that the mere detection of HGV RNA in serum samples would seriously underestimate the real prevalence of HGV infection in hemodialysis patients. Therefore, when assessing the prevalence of HGV infection in hemodialysis patients, detection of both antibody and nucleic acid is requisite.

摘要

通过检测病毒基因组和庚型肝炎病毒（HGV）E2抗体，对斯洛文尼亚丙型肝炎病毒感染率最高的透析单位的血液透析患者进行HGV感染率评估。59例血液透析患者中，7例（11.9%）检测到HGV RNA，20例（33.9%）检测到HGV E2抗体。研究时，有1例患者血清样本中同时检测到可检出的HGV RNA和HGV E2抗体。HGV感染的总发生率为44.1%。我们的结果清楚地表明，仅检测血清样本中的HGV RNA会严重低估血液透析患者中HGV感染的实际发生率。因此，在评估血液透析患者中HGV感染率时，同时检测抗体和核酸是必要的。