Jiroutek M R, Chen M H, Johnston C C, Longcope C
Dana-Farber Cancer Institute, Division of Biostatistics, Boston, Massachusetts, USA.
Menopause. 1998 Summer;5(2):90-4.
As part of a study on hormones and bone density in older women, we measured a number of steroid and polypeptide hormones at 4- to 6-month intervals in 32 women over a 10-year period.
All women were postmenopausal during this time and all measurements from 12 months after the menopause to the end were used in the analysis. To determine whether there was a significant trend in steroid or polypeptide hormones over the years, the data were analyzed by random coefficient linear regression against number of months since menopause.
There was no significant trend in the concentrations of estrone, estrone sulfate, dehydroepiandrosterone, and follicle stimulating hormone. There was a significant decline in the concentrations of estradiol, dihydrotestosterone, dehydroepiandrosterone sulfate, and luteinizing hormone. There was a rise in the levels of androstenedione and testosterone.
The changes in the concentration of sex hormone-binding globulin could be fitted to a quadratic equation with an initial rise in the concentration followed by a decline. Thus, the trend in hormone concentrations shows no set pattern with aging in the postmenopausal years.
作为一项关于老年女性激素与骨密度研究的一部分，我们在10年时间里，每隔4至6个月对32名女性的多种类固醇和多肽激素进行了测量。
在此期间，所有女性均已绝经，分析采用绝经后12个月至结束时的所有测量数据。为了确定多年来类固醇或多肽激素是否存在显著趋势，我们通过随机系数线性回归分析了绝经后月份数与这些激素之间的关系。
雌酮、硫酸雌酮、脱氢表雄酮和促卵泡激素的浓度没有显著趋势。雌二醇、双氢睾酮、硫酸脱氢表雄酮和促黄体生成素的浓度显著下降。雄烯二酮和睾酮水平上升。
性激素结合球蛋白浓度的变化可以用一个二次方程来拟合，即浓度先上升后下降。因此，绝经后几年中激素浓度的变化趋势并没有随着年龄增长呈现出固定模式。
