Song I O, Hong S R, Huh Y, Yoo K J, Koong M K, Jun J Y, Kang I S
Department of Gynecology and Obstetrics, Samsung Cheil Hospital, College of Medicine, Sung Kyun Kwan University, Seoul, Korea.
Am J Reprod Immunol. 1998 Jul;40(1):26-31. doi: 10.1111/j.1600-0897.1998.tb00384.x.
To determine the expression of vimentin and cytokeratin in eutopic and ectopic endometrium of women with both adenomyosis and ovarian endometrioma and to evaluate their cyclic changes during the menstrual cycle.
Twenty patients requiring hysterectomy with salpingo-oophorectomy were studied by immunohistochemistry according to their menstrual cycles.
Cyclic expression of vimentin was noted in eutopic endometrium and adenomyosis, but not in endometrioma. Cytokeratin expression did not change during the menstrual cycles. The mean intensities of epithelial vimentin were significantly different from each other, being the lowest in endometrioma, intermediate in adenomyosis, and the highest in eutopic endometrium. There was no significant difference in intensities of cytokeratin between adenomyosis and endometrioma, but these intensities were significantly lower than that of eutopic endometrium.
Lower intensities of cytokeratin in adenomyosis and endometrioma than in eutopic endometrium suggest that the ectopic endometria may have a lower degree of differentiation regardless of the site. The lower intensity of epithelial vimentin in endometrioma than in adenomyosis during the proliferative phase may reflect decreased functional activity, probably because of a pressure effect on the lining epithelium within the endometrioma.
确定同时患有子宫腺肌病和卵巢子宫内膜异位囊肿的女性在位和异位子宫内膜中波形蛋白和细胞角蛋白的表达，并评估它们在月经周期中的周期性变化。
对20例行子宫切除加输卵管卵巢切除术的患者，根据其月经周期进行免疫组织化学研究。
在位子宫内膜和子宫腺肌病中观察到波形蛋白的周期性表达，但在子宫内膜异位囊肿中未观察到。细胞角蛋白表达在月经周期中没有变化。上皮波形蛋白的平均强度彼此有显著差异，在子宫内膜异位囊肿中最低，在子宫腺肌病中居中，在位子宫内膜中最高。子宫腺肌病和子宫内膜异位囊肿之间细胞角蛋白强度没有显著差异，但这些强度显著低于在位子宫内膜。
子宫腺肌病和子宫内膜异位囊肿中细胞角蛋白强度低于在位子宫内膜，提示异位子宫内膜无论部位如何，分化程度可能较低。增殖期子宫内膜异位囊肿中上皮波形蛋白强度低于子宫腺肌病，可能反映功能活性降低，这可能是由于子宫内膜异位囊肿内衬上皮受到压力作用。
