[类固醇生成因子1在卵巢子宫内膜异位症和子宫腺肌病中的表达]
[Expression of steroidogenic factor 1 in ovarian endometriosis and adenomyosis].
作者信息
Xue Qing, Bai Lan, Li Ting, Dong Ying, Zhang Ying, Zhou Ying-fang
机构信息
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 2011 Nov;46(11):831-3.
OBJECTIVE
To investigate the expression of steroidogenic factor 1 (SF-1) in eutopic endometrium, ovarian endometriosis (EM) and adenomyosis.
METHODS
From Jan. 2008 to Dec. 2010, 30 patients with both ovarian endometriotic cysts and adenomyosis underwent hysterectomy, cystectomy or adenxectomy in Peking University First Hospital. The combination of ovarian EM and denomyosis were confirmed in 17 cases. In the mean time, endometria form 10 patients with cervical intraepithelial neoplasm (CIN) III underwent hysterectomy were selected as controls. The expression of SF-1 in eutopic endometrium, ovarian EM and adenomyosis was detected by immunohistochemistry staining.
RESULTS
No immunoreactivity of SF-1 was observed glandular cell and stromal cell in eutopic endometrium of both groups. 14/17 of positive rate of SF-1 were observed in lesions of ovarian endometriosis. SF-1 protein was not expressed in the endometrial glandular cells of ovarian EM and in adenomyosis foci.
CONCLUSION
The differences of SF-1 expression in ovarian endometrioma and adenomyosis foci might mediate the development of the disease.
目的
探讨类固醇生成因子1（SF-1）在在位内膜、卵巢子宫内膜异位症（EM）及子宫腺肌病中的表达情况。
方法
2008年1月至2010年12月，北京大学第一医院30例同时患有卵巢子宫内膜异位囊肿和子宫腺肌病的患者接受了子宫切除术、囊肿切除术或附件切除术。其中17例确诊为卵巢EM合并子宫腺肌病。同时，选取10例行子宫切除术的宫颈上皮内瘤变（CIN）III患者的子宫内膜作为对照。采用免疫组织化学染色法检测在位内膜、卵巢EM及子宫腺肌病中SF-1的表达。
结果
两组在位内膜的腺上皮细胞和间质细胞中均未观察到SF-1的免疫反应性。在卵巢子宫内膜异位症病灶中观察到SF-1的阳性率为14/17。SF-1蛋白在卵巢EM的子宫内膜腺上皮细胞及子宫腺肌病病灶中均未表达。
结论
卵巢子宫内膜瘤和子宫腺肌病病灶中SF-1表达的差异可能介导了疾病的发生发展。
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