Sawada M, Takada A, Takase S, Takada N
Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan.
Alcohol Alcohol Suppl. 1993;1B:85-90. doi: 10.1093/alcalc/28.supplement_1b.85.
We have reported that hepatitis C virus (HCV) RNA encoding the NS5 region (HCV-NS5) became negative following abstinence in some patients with alcoholic liver disease (ALD). In order to clarify the relationship between alcohol misuse (abuse) and the replication of HCV, serial changes of HCV-NS5 and the titer of HCV (HCV-titer) in blood after abstinence were studied in 11 male patients with ALD. Disappearance of HCV-NS5 after abstinence was found in five out of 11 patients (45%) and HCV-titer in blood decreased in all of these cases. In one patient, HCV-NS5 became positive and HCV-titers increased again following resumption of alcohol misuse. The etiology of liver disease in heavy drinkers was subdivided into three categories: alcohol alone, alcohol and HCV, and HCV alone, according to the diagnostic criteria of the Japanese research group for ALD. The etiology in four patients was a combination of alcohol and HCV, and was HCV alone in the remaining seven patients. In all four patients of the alcohol and HCV group, and one out of seven patients in the HCV alone group, HCV-NS5 became negative and HCV-titer decreased after abstinence. The decrease in HCV-titer was not related to the HCV genotypes. These results suggest that alcohol misuse may enhance the replication of HCV.
我们曾报道，在一些酒精性肝病（ALD）患者中，编码NS5区域的丙型肝炎病毒（HCV）RNA（HCV-NS5）在戒酒之后变为阴性。为了阐明酒精滥用与HCV复制之间的关系，我们对11例男性ALD患者戒酒之后血液中HCV-NS5和HCV滴度（HCV-titer）的系列变化进行了研究。11例患者中有5例（45%）在戒酒之后HCV-NS5消失，并且所有这些病例的血液中HCV滴度均下降。有1例患者在再次滥用酒精之后HCV-NS5变为阳性且HCV滴度再次升高。根据日本ALD研究组的诊断标准，重度饮酒者的肝病病因分为三类：单纯酒精、酒精和HCV、单纯HCV。4例患者的病因是酒精和HCV的组合，其余7例患者的病因是单纯HCV。在酒精和HCV组的所有4例患者以及单纯HCV组的7例患者中的1例，戒酒之后HCV-NS5变为阴性且HCV滴度下降。HCV滴度的下降与HCV基因型无关。这些结果提示，酒精滥用可能会增强HCV的复制。
