Dierker L C, Merikangas K R, Szatmari P
Wesleyan University, Department of Psychology, Middletown, CT 06459, USA.
J Am Acad Child Adolesc Psychiatry. 1999 Mar;38(3):280-8. doi: 10.1097/00004583-199903000-00015.
To examine the influence of parental mating types for substance abuse and anxiety/affective disorders on the risk of psychopathology among child and adolescent offspring.
Emotional and behavioral disorders were assessed in offspring, aged 7 to 17 years, of male and female parents who served as probands from a family study of comorbidity of substance abuse and anxiety disorders.
The findings indicated that (1) patterns of psychopathology among offspring were similar for mothers and fathers; (2) spouse concordance for psychopathology was greater among parents with substance abuse than among those with anxiety, particularly among female substance abusers; (3) there was a direct relationship between the number of affected parents and the magnitude of psychopathology in children, particularly with respect to the anxiety disorders; and (4) by contrast, rates of conduct disorder were elevated only among offspring of dually affected parents, irrespective of the specific parental disorders.
These findings underscore the importance of the contribution of both mothers and fathers, particularly those with concordance for psychiatric disorders, to the development of psychopathology in offspring.
探讨父母滥用药物及焦虑/情感障碍的配对类型对儿童及青少年后代精神病理学风险的影响。
对年龄在7至17岁的后代进行情绪和行为障碍评估，这些后代的父母（作为先证者）来自一项药物滥用与焦虑障碍共病的家庭研究。
研究结果表明：（1）母亲和父亲的后代精神病理学模式相似；（2）滥用药物的父母之间精神病理学的配偶一致性高于患有焦虑症的父母，尤其是女性药物滥用者；（3）受影响父母的数量与儿童精神病理学的严重程度之间存在直接关系，特别是在焦虑症方面；（4）相比之下，品行障碍的发生率仅在双亲均受影响的后代中升高，而与父母具体的疾病无关。
这些发现强调了母亲和父亲，特别是那些患有精神疾病且一致的父母，对后代精神病理学发展的重要贡献。
