Chodobski A, Szmydynger-Chodobska J, McKinley M J
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.
Am J Physiol. 1998 Aug;275(2):F235-8. doi: 10.1152/ajprenal.1998.275.2.F235.
Cerebrospinal fluid (CSF) plays an important role in the brain's adaptive response to acute osmotic disturbances. In the present experiments, the effect of 48-h dehydration on CSF formation and absorption rates was studied in conscious adult sheep. Animals had cannulas chronically implanted into the lateral cerebral ventricles and cisterna magna to enable the ventriculocisternal perfusion. A 48-h water deprivation altered neither CSF production nor resistance to CSF absorption. However, in the water-depleted sheep, intraventricular pressure tended to be lower than that found under control conditions. This likely resulted from decreased extracellular fluid volume and a subsequent drop in central venous pressure occurring in dehydrated animals. In conclusion, our findings provide evidence for the maintenance of CSF production during mild dehydration, which may play a role in the regulation of fluid balance in the brain during chronic hyperosmotic stress.
脑脊液（CSF）在大脑对急性渗透压紊乱的适应性反应中起着重要作用。在本实验中，研究了48小时脱水对清醒成年绵羊脑脊液生成和吸收速率的影响。动物长期植入侧脑室和小脑延髓池的套管，以进行脑室-脑池灌注。48小时禁水既未改变脑脊液生成，也未改变脑脊液吸收阻力。然而，在缺水的绵羊中，脑室内压往往低于对照条件下的水平。这可能是由于脱水动物细胞外液体积减少以及随后中心静脉压下降所致。总之，我们的研究结果为轻度脱水期间脑脊液生成的维持提供了证据，这可能在慢性高渗应激期间大脑液体平衡的调节中发挥作用。
