Romanov V V, Ozerova L V, Stepanian I E
Probl Tuberk. 1998(3):55-7.
Fifty one patients with alveolitis of different genesis (idiopathic fibrotic alveolitis (IFA) in 15, extrinsic allergic alveolitis (EAA) in 20, fibrotic alveolitis (FA) in 10, and eosinophilic pneumonias (EP) in 6), receiving multimodality therapy had a session of plasmapheresis (PA) including 3-4 procedures at a week interval. The session was repeated in 4 patients. The earliest results in all patients appeared as better well-being, improved parameters of blood and external respiratory function and half the patients had positive X-ray changes. The best results were achieved by patients with EP, the worst by those with IFA. Following 2 years, remission retained in a third of patients, recrudescence was noted in two thirds. Five patients with IFA and EAA died. In most patients PA was started late when they had developed recrudescence and respiratory failure. Ineffective therapy made the authors think of PA. The latter improved all the patients' condition and yielded early positive changes in many parameters. PA may have a positive impact in the late period.
51例不同病因的肺泡炎患者（特发性肺纤维化肺泡炎（IFA）15例、外源性过敏性肺泡炎（EAA）20例、肺纤维化肺泡炎（FA）10例、嗜酸性粒细胞性肺炎（EP）6例）接受多模式治疗，进行了一轮血浆置换（PA），包括每隔一周进行3 - 4次操作。4例患者重复了该疗程。所有患者最早出现的结果是身体状况改善、血液和肺外呼吸功能参数好转，一半患者X线有阳性改变。EP患者取得的效果最佳，IFA患者最差。2年后，三分之一的患者保持缓解，三分之二有复发。5例IFA和EAA患者死亡。大多数患者在复发和呼吸衰竭时才开始进行血浆置换，治疗效果不佳促使作者考虑采用血浆置换。血浆置换改善了所有患者的病情，并在许多参数上产生了早期阳性变化。血浆置换在后期可能有积极影响。
