Makhmudova S Iu
Georgian Med News. 2009 May(170):54-6.
To study some indicators of cytokine status among the patients with pneumonia alveolitis 89 patients have been examined. 60 of those patients suffer from exogenous allergic alveolitis (EAA) and - 60 from idiopathic fibrosing alveolitis (IFA). The average age is 36.4+/-3.0. The patients were devided into three groups: I group - 21 (23.6%) patients with acute disease, II group - 25 (28.1%) patients with subacute disease, III group - 43 (48.3%) patients with chronic disease. The level of IL-1beta and IL-8 in blood serum and bronchoalveolar wash-out (BWO) measured by IFA test system. It is identified that the contents of IL-1beta in blood serum of EAA patients exceeded on 7.2%, the contents of IL-8 exceeded on 14.6% among IFA patients - reliable rise IL-1beta on 35.4% (<0.05) and IL-8 on 31.6% (<0.05). The level of proinflammatory cytokines (IL-1beta and IL-8) in peripheric blood corresponded with the level of disease. Along with progressing of disease the contents of cytokine in respiratory space, too high, increased among 21 patients with acute disease, in 13 cases (61.9%) BWO was high in IL-1beta and in 80.8% cases of IL-8. in II group among 25 patients with subacute disease high level of IL-1beta marked in 56.0%, Il-8 in 84% cases; patients in III group high concentration of IL-1beta registered in 51.2%; Il-8 in 81.4% of patients.
为研究肺泡炎患者的细胞因子状态指标，对89例患者进行了检查。其中60例患有外源性过敏性肺泡炎（EAA），60例患有特发性肺纤维化肺泡炎（IFA）。平均年龄为36.4±3.0岁。患者被分为三组：I组 - 21例（23.6%）急性病患者，II组 - 25例（28.1%）亚急性病患者，III组 - 43例（48.3%）慢性病患者。采用IFA检测系统测量血清和支气管肺泡灌洗液（BWO）中IL-1β和IL-8的水平。结果发现，EAA患者血清中IL-1β含量超过7.2%，IFA患者中IL-8含量超过14.6%，IL-1β可靠升高35.4%（<0.05），IL-8升高31.6%（<0.05）。外周血中促炎细胞因子（IL-1β和IL-8）水平与疾病程度相符。随着疾病进展，呼吸道空间中的细胞因子含量也升高，21例急性病患者中，13例（61.9%）BWO中IL-1β含量高，80.8%的病例中IL-8含量高。II组25例亚急性病患者中，56.0%的患者IL-1β水平高，84%的病例中IL-8水平高；III组患者中，51.2%的患者IL-1β浓度高，81.4%的患者IL-8浓度高。
