Dalbey W, Dunn B, Bannister R, Daughtrey W, Kirwin C, Reitman F, Steiner A, Bruce J
Mobil Business Resources Corporation, Paulsboro, New Jersey 08066, USA.
Regul Toxicol Pharmacol. 1998 Jun;27(3):207-16. doi: 10.1006/rtph.1998.1203.
A series of acute inhalation exposures of female rats was conducted with hydrogen fluoride (HF) to establish a concentration-response curve for nonlethal exposures. Durations of 2 and 10 min were used to simulate possible short-term exposures. Concentrations of HF ranged from 593 to 8621 ppm for 2-min exposures and from 135 to 1764 ppm for 10-min exposures. Additional exposures were performed for 60 min at 20 and 48 ppm HF for comparison to existing Emergency Response Planning Guidelines. Animals were evaluated on the day after exposure for changes in parameters of bronchoalveolar lavage, pulmonary function, hematology, serum chemistry, body weight, organ weights, and histopathology. Most exposures were performed with orally cannulated animals to bypass absorption of HF in the nose and achieve maximum delivery of HF to the lower airways. One of the primary uses of the resulting data was to estimate a concentration to which most people could be exposed for 10 min without severe of irreversible health effects. This level was 130 ppm. It was predicted that irritation would occur at this concentration, but the effects on t he respiratory tract would not be "serious" and would be expected to be reversible. The results of this experiment and the subsequent analysis of the data provide an important aid in he planning of responses to an accidental release of HF.
对雌性大鼠进行了一系列氟化氢（HF）急性吸入暴露实验，以建立非致死性暴露的浓度-反应曲线。采用2分钟和10分钟的暴露时长来模拟可能的短期暴露。2分钟暴露时HF浓度范围为593至8621 ppm，10分钟暴露时浓度范围为135至1764 ppm。另外，在20 ppm和48 ppm的HF浓度下进行了60分钟的暴露，以便与现有的应急响应规划指南进行比较。在暴露后的第二天对动物进行评估，观察支气管肺泡灌洗、肺功能、血液学、血清化学、体重、器官重量和组织病理学等参数的变化。大多数暴露实验使用经口插管的动物，以绕过HF在鼻腔的吸收，使HF最大程度地输送到下呼吸道。所得数据的一个主要用途是估算大多数人在10分钟内可暴露而不会产生严重或不可逆健康影响的浓度。该浓度为130 ppm。据预测，在此浓度下会出现刺激反应，但对呼吸道的影响不会“严重”，且预计是可逆的。该实验结果及后续数据分析为规划应对HF意外泄漏的措施提供了重要帮助。
