Kovalev I E, Shaĭdrov V V, Polevaia O Iu
Farmakol Toksikol. 1976 Mar-Apr;39(2):221-5.
Experiments conducted on mice immunized with sheep's erythrocytes proved that phenobarbital, even in toxic doses does not produce any immunodepressive effect. But when it is covalently bound by the diazo-method with a protein-carrier phenobarbital becomes a strong immunodepressant. Then, however, it does not affect the central nervous system, nor influence the immunodepressive activity of cyclophosphamide--an agent metabolically activated in the liver. Free phenobarbital mitigates the effect of cyclophosphamide on the immunological response in mice.
对用绵羊红细胞免疫的小鼠进行的实验证明，即使是毒性剂量的苯巴比妥也不会产生任何免疫抑制作用。但是，当通过重氮法将其与蛋白质载体共价结合时，苯巴比妥就会成为一种强效免疫抑制剂。然而，此时它既不影响中枢神经系统，也不影响环磷酰胺的免疫抑制活性，环磷酰胺是一种在肝脏中被代谢激活的药物。游离的苯巴比妥会减轻环磷酰胺对小鼠免疫反应的影响。
