Frey J M, Mintzer M Z, Rush C R, Griffiths R R
Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Psychopharmacology (Berl). 1998 Jul;138(1):16-26. doi: 10.1007/s002130050640.
The discriminative stimulus effects of buspirone and diazepam were examined in 12 healthy volunteers using a three-response drug discrimination procedure and a within-subject design. During an initial sampling phase, the training drug conditions (placebo, 15 mg/70 kg buspirone, and 10 mg/70 kg diazepam) were identified to subjects by letter codes before oral drug administration. During a subsequent training phase, subjects earned money for correct drug identifications made two hours after drug administration. Ten out of 12 subjects acquired the three-response discrimination. When lower doses of buspirone (3.75 and 7.5 mg/70 kg) and diazepam (2.5 and 5.0 mg/70 kg) were tested in a subsequent generalization testing phase, both buspirone and diazepam produced dose-related increases in appropriate drug identifications, without significant cross-generalization. Analyses of standardized and unstructured self report questionnaires revealed that buspirone and diazepam produced different profiles of effects, and that buspirone was associated with a number of "negative" subject-rated effects including tension, nausea, and dizziness. These results demonstrate a distinct profile of discriminative stimulus and subjective effects for buspirone relative to diazepam which is consistent with its distinct pharmacological profile, and provide evidence for the sensitivity of the three-response drug discrimination procedure.
采用三反应药物辨别程序和被试内设计，在12名健康志愿者中研究了丁螺环酮和地西泮的辨别刺激效应。在初始取样阶段，在口服给药前，通过字母代码向被试确定训练药物条件（安慰剂、15mg/70kg丁螺环酮和10mg/70kg地西泮）。在随后的训练阶段，被试在给药两小时后正确识别药物可获得金钱奖励。12名被试中有10名获得了三反应辨别能力。在随后的泛化测试阶段，当测试较低剂量的丁螺环酮（3.75和7.5mg/70kg）和地西泮（2.5和5.0mg/70kg）时，丁螺环酮和地西泮均使适当的药物识别呈剂量相关增加，且无明显的交叉泛化。对标准化和非结构化自我报告问卷的分析表明，丁螺环酮和地西泮产生不同的效应特征，且丁螺环酮与一些“负面”的被试评定效应相关，包括紧张、恶心和头晕。这些结果表明，相对于地西泮，丁螺环酮具有独特的辨别刺激和主观效应特征，这与其独特的药理学特征一致，并为三反应药物辨别程序的敏感性提供了证据。
