海马体损伤对纹状体边缘离子型谷氨酸能受体的影响。

Effects of hippocampal lesions on striatolimbic ionotropic glutamatergic receptors.

作者信息

Tarazi F I, Campbell A, Baldessarini R J

机构信息

Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont 02178, USA.

出版信息

Neurosci Lett. 1998 Jun 26;250(1):13-6. doi: 10.1016/s0304-3940(98)00433-9.

DOI:10.1016/s0304-3940(98)00433-9

PMID:9696054

Abstract

Changes in ionotropic N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate glutamatergic (Glu) receptor binding in rat caudate putamen (CPu) and nucleus accumbens (NAc) and hippocampal CA1 and CA3 regions were examined after unilateral injections of kainic acid (KA) into hippocampus to degenerate local intrinsic neurons and remove the glutamatergic afferents projecting to CPu and NAc. KA injections produced large losses of NMDA, AMPA and kainate receptors in hippocampal CA1 and CA3 regions. In addition, NMDA and kainate, but not AMPA, receptors were significantly reduced in NAc and CPu. These results suggest that a large proportion of NMDA, AMPA and kainate receptors in rat hippocampus arise on intrinsic postsynaptic neurons, and that some NMDA and kainate, but not AMPA, receptors also occur on presynaptic terminals of hippocampostriatal afferents innervating the CPu and NAc.

摘要

在向海马体单侧注射海藻酸（KA）以使局部固有神经元退化并去除投射到尾壳核（CPu）和伏隔核（NAc）的谷氨酸能传入神经后，检测了大鼠尾壳核、伏隔核以及海马CA1和CA3区离子型N-甲基-D-天冬氨酸（NMDA）、α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）和海人藻酸谷氨酸能（Glu）受体结合的变化。注射KA导致海马CA1和CA3区的NMDA、AMPA和海人藻酸受体大量丧失。此外，NAc和CPu中的NMDA和海人藻酸受体显著减少，但AMPA受体未减少。这些结果表明，大鼠海马体中很大一部分NMDA、AMPA和海人藻酸受体存在于固有突触后神经元上，并且一些NMDA和海人藻酸受体（而非AMPA受体）也存在于支配CPu和NAc的海马纹状体传入神经的突触前终末上。