Campbell A J, Bolton D P, Taylor B J, Sayers R M
Department of Paediatrics and Child Health, Dunedin School of Medicine and School of Medical Sciences, New Zealand.
Respir Physiol. 1998 Apr;112(1):51-8. doi: 10.1016/s0034-5687(98)00008-5.
Infants aged 0-6 months were assessed for respiratory and arousal responses to mild asphyxia during sleep. Ventilatory sensitivity was assessed from the relationship between inspired carbon dioxide (FICO2) and ventilation. Arousal and ventilatory sensitivity were significantly related. Respiratory response increased with age and was greater in quiet sleep than in REM sleep. Arousal occurred more frequently in REM sleep (55/102) than quiet sleep (38/165, P < 0.05) and more frequently at the newborn age (54/117) than at 6 months (13/58, P < 0.05). Arousal in quiet sleep occurred in babies with high ventilatory sensitivities (mean ventilatory asphyxial sensitivity (VAS) 0.476 +/- 0.288) and in REM sleep was more associated with low ventilatory sensitivities (mean VAS 0.194 +/- 0.334, P <0.05). We conclude infants respond to mild asphyxia during sleep with an increase in ventilation, an arousal or both. The exact response is dependent on age and sleep state.
对0至6个月大的婴儿在睡眠期间对轻度窒息的呼吸和觉醒反应进行了评估。根据吸入二氧化碳（FICO2）与通气之间的关系评估通气敏感性。觉醒与通气敏感性显著相关。呼吸反应随年龄增长而增加，且在安静睡眠时比快速眼动睡眠时更大。觉醒在快速眼动睡眠（55/102）中比安静睡眠（38/165，P<0.05）中更频繁发生，在新生儿期（54/117）比6个月时（13/58，P<0.05）更频繁发生。安静睡眠中的觉醒发生在通气敏感性高的婴儿中（平均通气窒息敏感性（VAS）0.476±0.288），而快速眼动睡眠中的觉醒与低通气敏感性更相关（平均VAS 0.194±0.334，P<0.05）。我们得出结论，婴儿在睡眠期间对轻度窒息的反应是通气增加、觉醒或两者兼有。确切的反应取决于年龄和睡眠状态。
