Wolfgang G, Marcus D, Ulrike S
Neurologic Department Kaiser Franz Josef Spital, Vienna, Austria.
J Neurooncol. 1998 Jun-Jul;38(2-3):103-10. doi: 10.1023/a:1005910203831.
Leptomeningeal carcinomatosis (LC) occurs in solid tumors like breast, lung carcinoma and melanoma, rarely sarcoma and in leukemia and lymphoma. Clinical symptoms of LC often present with differential diagnostic problems. The most common presentation are multiple neuraxis syndromes which for didactic reasons are classically considered as central nervous system (CNS), spinal (SP) or cranial nerve (CN) symptoms and signs and appear isolated or more frequently in combinations. It is generally agreed that signs are usually more prominent than symptoms. Only few series focus on monolocular presentation at clinical manifestation. This overview describes the clinical symptoms and signs in patients with LC, the concept of multiple neuraxis lesions, CNS, CN and SP signs and symptoms. Also the problem of new symptoms and signs in patients treated with antineoplastic chemotherapy and radiation is addressed. The study is based on own results and a survey of the present literature.
柔脑膜癌病（LC）发生于实体瘤，如乳腺癌、肺癌和黑色素瘤，肉瘤、白血病和淋巴瘤中较少见。LC的临床症状常存在鉴别诊断问题。最常见的表现是多发性神经轴综合征，出于教学目的，经典地将其视为中枢神经系统（CNS）、脊髓（SP）或颅神经（CN）症状和体征，可单独出现或更常见地合并出现。普遍认为体征通常比症状更明显。仅有少数系列研究关注临床表现时的单眼表现。本综述描述了LC患者的临床症状和体征、多发性神经轴病变的概念、CNS、CN和SP的体征和症状。此外，还讨论了接受抗肿瘤化疗和放疗患者出现新症状和体征的问题。本研究基于自身结果及对现有文献的调查。
