Deng Yongyan, Li Wenyue, Zhang Bin
The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China.
Peking University Sixth Hospital, Beijing 100191, China.
J Pers Med. 2023 Feb 24;13(3):405. doi: 10.3390/jpm13030405.
Depression is a long-lasting mental disorder that affects more than 264 million people worldwide. Transcranial magnetic stimulation (TMS) can be a safe and effective choice for the treatment of depression. Functional neuroimaging provides unique insights into the neuropsychiatric effects of antidepressant TMS. In this meta-analysis, we aimed to assess the functional activity of brain regions caused by TMS for depression. A literature search was conducted from inception to 5 January 2022. Studies were then selected according to predetermined inclusion and exclusion criteria. Activation likelihood estimation was applied to analyze functional activation. Five articles were ultimately included after selection. The main analysis results indicated that TMS treatment for depression can alter the activity in the right precentral gyrus, right posterior cingulate, left inferior frontal gyrus and left middle frontal gyrus. In resting-state studies, increased activation was shown in the right precentral gyrus, right posterior cingulate, left inferior frontal gyrus and left superior frontal gyrus associated with TMS treatment. In task-related studies, clusters in the right middle frontal gyrus, left sub-gyrus, left middle frontal gyrus and left posterior cingulate were hyperactivated post-treatment. Our study offers an overview of brain activity changes in patients with depression after TMS treatment.
抑郁症是一种持久性精神障碍，全球有超过2.64亿人受其影响。经颅磁刺激（TMS）可以成为治疗抑郁症的一种安全有效的选择。功能神经影像学为抗抑郁TMS的神经精神效应提供了独特的见解。在这项荟萃分析中，我们旨在评估TMS治疗抑郁症所引起的脑区功能活动。从开始到2022年1月5日进行了文献检索。然后根据预先确定的纳入和排除标准选择研究。应用激活可能性估计来分析功能激活。经过筛选，最终纳入了五篇文章。主要分析结果表明，TMS治疗抑郁症可改变右侧中央前回、右侧后扣带回、左侧额下回和左侧额中回的活动。在静息状态研究中，与TMS治疗相关的右侧中央前回、右侧后扣带回、左侧额下回和左侧额上回显示激活增加。在任务相关研究中，治疗后右侧额中回、左侧中央回、左侧额中回和左侧后扣带回的簇状区域过度激活。我们的研究概述了抑郁症患者接受TMS治疗后脑活动的变化。
