农杆菌VirE2蛋白可在植物细胞质中与T链形成复合物。
Agrobacterium VirE2 proteins can form a complex with T strands in the plant cytoplasm.
作者信息
Gelvin S B
机构信息
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-1392, USA.
出版信息
J Bacteriol. 1998 Aug;180(16):4300-2. doi: 10.1128/JB.180.16.4300-4302.1998.
Abstract
Wild-type VirE2 and VirD2 proteins from Agrobacterium tumefaciens contain nuclear targeting sequences (NLS) that are likely involved in directing transferred T strands to the plant nucleus. An A. tumefaciens virE2 virD2DeltaNLS double mutant was able to form tumors on VirE2-producing transgenic tobacco but not on wild-type tobacco. Because this mutant bacterial strain contains no known T-strand nuclear targeting signal, the data indicate that wild-type VirE2 proteins produced by the plant can interact with the T strands in the plant cytoplasm and direct them to the nucleus.
摘要
根癌土壤杆菌的野生型VirE2和VirD2蛋白含有核定位序列（NLS），这些序列可能参与将转移的T链导向植物细胞核。根癌土壤杆菌virE2 virD2DeltaNLS双突变体能够在产生VirE2的转基因烟草上形成肿瘤，但不能在野生型烟草上形成肿瘤。由于这种突变细菌菌株不包含已知的T链核定位信号，数据表明植物产生的野生型VirE2蛋白可以与植物细胞质中的T链相互作用并将它们导向细胞核。
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pSa causes oncogenic suppression of Agrobacterium by inhibiting VirE2 protein export.pSa通过抑制VirE2蛋白输出对根癌土壤杆菌产生致癌抑制作用。
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