Heyden S, Tyroler H A, Cassel J C, Hames C G, Becker C, Heiss G
Z Ernahrungswiss. 1976 Jun;15(2):143-50. doi: 10.1007/BF02018434.
Total mortality showed no association with heavy coffee consumption in the four race-sex groups of Evans County. Deaths from coronary heart disease in WM, WF and BM showed no statistically significant differences between the two coffee consuming groups. Sex differences in cerebrovascular death rates, consistent in both races, suggest the possibility for a female excess of stroke deaths among coffee drinkers, and a "protective" effect of coffee drinking among males. Thus, in an area of the United States which has been designated the "Stroke Belt", neither the cardiovascular nor the cerebrovascular death rates seem strongly nor consistently related to coffee drinking habits. Although the number of deaths (339) is fairly large, representing a 13% mortality in this community over a four and one-half year observation period, the classification in four race-sex groups with further division into the groups with different coffee drinking habits limits each stratum to rather small numbers. In addition, 86 cases of CHD and CVD were diagnosed during lifetime already and, therefore, were excluded from the prospective mortality study. Confidently to refute or confirm the allegations of a detrimental influence of high coffee intake on ischemic heart disease one would need larger numbers. But in the light of our most important finding--that mortality from all causes is not increased in the high coffee consuming group--the finding of increased ischemic heart disease death rates with high coffee consumption would have to be compensated by a provocative, lower rate for other causes of death.
在埃文斯县的四个种族 - 性别组中,总死亡率与大量饮用咖啡之间没有关联。在白人男性(WM)、白人女性(WF)和黑人男性(BM)中,冠心病死亡在两个咖啡饮用组之间没有统计学上的显著差异。两个种族的脑血管死亡率的性别差异表明,咖啡饮用者中女性中风死亡人数可能较多,而咖啡饮用对男性有“保护”作用。因此,在美国一个被指定为“中风带”的地区,心血管和脑血管死亡率似乎都与咖啡饮用习惯没有强烈且一致的关联。尽管死亡人数(339人)相当多,在四年半的观察期内占该社区死亡率的13%,但按四个种族 - 性别组分类,并进一步细分为不同咖啡饮用习惯的组,使得每个阶层的人数都相当少。此外,有86例冠心病和心血管疾病病例在生前已被诊断出来,因此被排除在预期死亡率研究之外。要确凿地反驳或证实高咖啡摄入量对缺血性心脏病有不利影响的说法,需要更多的样本量。但鉴于我们最重要的发现——高咖啡饮用组的全因死亡率没有增加——高咖啡摄入量导致缺血性心脏病死亡率增加这一发现,必须由其他死因的较低发生率来抵消。