Quiles J L, Huertas J R, Mañas M, Battino M, Ochoa J J, Mataix J
Departamento de Fisiología, Universidad de Granada, Spain.
Biofactors. 1998;8(1-2):119-27. doi: 10.1002/biof.5520080120.
Plasma is an important vehicle through which antioxidant molecules are conveyed and in which they may show different behaviors, either acting as a protective factor for oxidative damage to different blood elements or using it as a vehicle through which dietary antioxidant factors would be distributed to the body. The aim of the study was to determine the plasma level of vitamin E, coenzyme Q, uric acid and vitamin A and their relation with the cellular oxidative damage mediated by physical training and the ingestion of different fat (virgin olive and sunflower oils). Male Wistar rats were divided into 8 subgroups based on the dietary fat intake and their physical activity. Results show that both dietary fat and physical training affect susceptibility to iron-induced lipid peroxidation in plasma and the tissues that were studied. The increase of this lipid peroxidation parallels a decrease of the level of all the plasma antioxidants that were studied.
血浆是抗氧化分子运输的重要载体，在其中它们可能表现出不同行为，既可以作为对不同血液成分氧化损伤的保护因子，也可以作为膳食抗氧化因子向身体分布的载体。本研究的目的是测定维生素E、辅酶Q、尿酸和维生素A的血浆水平，以及它们与体育锻炼和摄入不同脂肪（初榨橄榄油和葵花籽油）介导的细胞氧化损伤之间的关系。雄性Wistar大鼠根据膳食脂肪摄入量和身体活动情况分为8个亚组。结果表明，膳食脂肪和体育锻炼均会影响血浆及所研究组织中铁诱导的脂质过氧化敏感性。这种脂质过氧化的增加与所研究的所有血浆抗氧化剂水平的降低平行。
