Ladevèze V, Aulard S, Chaminade N, Périquet G, Lemeunier F
Institut de Biologie Moléculaire et d'Ingenierie Génétique, Université de Poitiers, ESA 6031, France.
Proc Biol Sci. 1998 Jul 7;265(1402):1157-9. doi: 10.1098/rspb.1998.0412.
Several laboratory surveys have shown that transposable elements (TEs) can cause chromosomal breaks and lead to inversions, as in dysgenic crosses involving P-elements. However, it is not presently clear what causes inversions in natural populations of Drosophila. The only direct molecular studies must be taken as evidence against the involvement of mobile elements. Here, in Drosophila lines transformed with the hobo transposable element, and followed for 100 generations, we show the appearance of five different inversions with hobo inserts at breakpoints. Almost all breakpoints occurred in hobo insertion sites detected in previous generations. Therefore, it can be assumed that such elements are responsible for restructuring genomes in natural populations.
多项实验室研究表明，转座元件（TEs）可导致染色体断裂并引发倒位，就像在涉及P元件的杂种不育杂交中那样。然而，目前尚不清楚在果蝇自然种群中是什么导致了倒位。唯一的直接分子研究必须被视为反对移动元件参与其中的证据。在这里，在用hobo转座元件转化并追踪了100代的果蝇品系中，我们展示了五个不同的倒位的出现，其断点处有hobo插入。几乎所有断点都出现在前几代检测到的hobo插入位点。因此，可以假定这些元件在自然种群中负责基因组的重组。
