Benavides E, Wulf A, Rahmer A, Zúñiga A, Aguayo G, Oyarzún E, Quintana C
Departamento de Gastroenterología, Hospital Clínico Pontificia Universidad Católica de Chile, Santiago, Chile.
Rev Med Chil. 1998 Apr;126(4):363-6.
The evolution of ulcerative colitis in pregnancy is far from clear. While some authors state that the disease aggravates during this period, others do not share this opinion.
To assess the evolution of ulcerative colitis in pregnancy.
A paired case-control design was used in which 15 women, with diagnosed ulcerative colitis at the moment of becoming pregnant, were followed for 12 months and the activity of the disease was compared with that of the 12 months preceding the pregnancy. The activity of the disease in the period preceding the pregnancy was gathered retrospectively from the patient's charts.
The mean age of the first ulcerative colitis crisis was 24 years. It was moderate in 49% and severe in 35% of women. During pregnancy 55% of women did not have a crisis, compared with 26.7% during the period preceding pregnancy (relative risk of not having a crisis during pregnancy of 1.7). During both periods, seven women had digestive complications, whereas extra digestive complications were not observed in 60% of patients during pregnancy and 11.8% of patients during the preceding period. Perinatal results were similar to those of the general population.
In our group of patients the evolution of ulcerative colitis was better during pregnancy, reflected by a lower number of crisis.
妊娠期溃疡性结肠炎的病情发展尚不清楚。一些作者认为在此期间病情会加重，而另一些人则不认同这一观点。
评估妊娠期溃疡性结肠炎的病情发展。
采用配对病例对照设计，对15名在怀孕时被诊断为溃疡性结肠炎的女性进行了为期12个月的随访，并将疾病活动度与怀孕前12个月的情况进行比较。怀孕前阶段的疾病活动度是通过回顾患者病历收集的。
首次溃疡性结肠炎发作的平均年龄为24岁。49%的女性病情为中度，35%为重度。孕期55%的女性未发作，而怀孕前阶段这一比例为26.7%（孕期未发作的相对风险为1.7）。在两个阶段中，均有7名女性出现消化系统并发症，孕期60%的患者和怀孕前阶段11.8%的患者未出现消化系统外的并发症。围产期结果与一般人群相似。
在我们的患者群体中，妊娠期溃疡性结肠炎的病情发展较好，表现为发作次数较少。
