白细胞介素-13在鼻黏膜嗜酸性粒细胞炎症中的潜在作用。

The potential role of interleukin-13 in eosinophilic inflammation in nasal mucosa.

作者信息

Terada N, Hamano N, Hohki G, Ikeda T, Sai M, Yamashita T, Konno A

机构信息

Department of Otorhinolaryngology, Chiba University, School of Medicine, Chiba City, Japan.

出版信息

Allergy. 1998 Jul;53(7):690-7. doi: 10.1111/j.1398-9995.1998.tb03955.x.

DOI:10.1111/j.1398-9995.1998.tb03955.x

PMID:9700038

Abstract

BACKGROUND

Recent studies have revealed that interleukin (IL)-13, as well as IL-4, causes de novo surface expression of vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells of the umbilical vein and accelerates selective eosinophil migration. However, its role in allergic rhinitis remains to be clarified. Of particular interest is whether IL-13 upregulates VCAM-1 expression in human mucosal microvascular endothelial cells (HMMECs), to which eosinophils adhere in nasal mucosa.

METHODS

To understand the potential role of IL-13 in eosinophilic inflammation in nasal mucosa, we examined the effects of IL-13 on the adhesiveness between HMMECs and eosinophils.

RESULTS

IL-13 increased VCAM-1 expression in HMMECs, the adhesiveness of endothelial cells to eosinophils, and the transendothelial migration. On the other hand, IL-13 decreased the adhesiveness of eosinophils to HMMECs, and, as a result, accelerated eosinophil infiltration. Those effects are more potent than was those of IL-4. In addition, we also report that the amount of IL-13 in nasal mucosa was higher than that of IL-4.

CONCLUSIONS

These results strongly indicate that IL-13, as well as IL-4, may be important in eosinophilic inflammation in the nasal mucosa.

摘要

背景

最近的研究表明，白细胞介素（IL）-13以及IL-4可导致脐静脉内皮细胞表面从头表达血管细胞黏附分子-1（VCAM-1），并加速选择性嗜酸性粒细胞迁移。然而，其在变应性鼻炎中的作用仍有待阐明。特别值得关注的是，IL-13是否上调人黏膜微血管内皮细胞（HMMECs）中VCAM-1的表达，嗜酸性粒细胞在鼻黏膜中黏附于该细胞。