Topciu V, Braga V, Plavoşin L, Schiopu S, Moldovan E, Lazăr E
Zentralbl Bakteriol Orig B. 1976 Mar;161(5-6):551-6.
We studied 608 antivariolic revaccinated pregnants in spring 1972 at different ages of gestation. 60 presented spontaneous abortus; in 502 cases there has been performed therapeutical abortion, and 46 pregnants revaccinated after 2 1/2-3 months of gestation continued their pregnancy. Pregnancy and birth in revaccinated pregnants which did not abort, evolved without any difference against the witness-sample; the newborns presented in a higher percentage underweight. The absence of the vaccinia-virus and of Guarnieri-inclusions in the examined placentae and embryos as well as the moment of abortion, only after 20 days from the revaccination data, leads to the supposition that the placental lesions do not seem to be produced by the direct action of the virus by its replication, but probably by reactions of hypersensibility of the late type against the alergizin antigens of the antismallpox vaccine. The antivariolic revaccination of the sample of pregnants, showed that the vaccinia virus did not present a malformative action upon the embryo, but in change the abortive action was manifest in indirect proportion to the age of gestation.
1972年春季，我们对608名在不同妊娠阶段再次接种抗天花疫苗的孕妇进行了研究。60人自然流产；502例进行了治疗性流产，46例在妊娠2个半月至3个月后再次接种疫苗的孕妇继续妊娠。未流产的再次接种疫苗的孕妇的妊娠和分娩过程与对照组相比没有任何差异；新生儿体重不足的比例更高。在所检查的胎盘和胚胎中没有痘苗病毒和瓜尔尼里小体，以及仅在再次接种疫苗20天后才出现流产，这使得人们推测胎盘病变似乎不是由病毒复制的直接作用产生的，而是可能由对天花疫苗的变应原抗原的迟发型超敏反应引起的。对孕妇样本进行的抗天花再次接种表明，痘苗病毒对胚胎没有致畸作用，但流产作用与妊娠年龄成反比。
